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“They dug holes very, very deep,” he said. That’s my interpretation,” Moldea told The Associated Press. … My impression today was them breaking the bad news to me: Thanks for the tip but this is over. He said the FBI and its contractors did not dig in the exact spot that he had recommended. Schneider declined to comment further when asked for details about the excavation.Īuthorities believe Hoffa disappeared in suburban Detroit in 1975 while meeting with reputed mobsters.ĭan Moldea, a journalist who has written extensively about the Hoffa saga, said he was personally briefed by the FBI in a video conference call Thursday. July 21, 2022: The FBI says it found no evidence of Hoffa during a search of land under a New Jersey bridge. 19, 2021: FBI says it obtained a search warrant for a “site survey underneath the Pulaski Skyway” in New Jersey. June 17, 2013: The FBI sees enough merit in a reputed Mafia captain’s tip to once again break out the digging equipment to search for Hoffa’s remains in an Oakland Township field, about 25 miles north of Detroit. May 17, 2006: The FBI begins searching a horse farm in Oakland County’s Milford Township, northwest of Detroit for Hoffa’s remains, but ends the search after finding nothing. Kuklinski’s book, “The Ice Man: Confessions of a Mafia Contract Killer,” contends he received $40,000 for the slaying. The FBI crime lab would conclude that the blood found on the floorboards was not Hoffa’s.Īpril 2006: New Jersey mob hit man Richard “The Iceman” Kuklinski, who died in March, claims that he killed Hoffa and put his body in a car that was sold as scrap metal. May 2004: Bloomfield Township police rip up the floorboards from a Detroit house where one-time Hoffa ally Frank Sheeran claims to have killed him. 29, 2002: Oakland County prosecutor says new DNA evidence in Hoffa’s disappearance is insufficient to bring criminal charges. John Bell, special agent in charge of the FBI’s Detroit bureau, says the federal case was stymied because of the length of time since Hoffa disappeared.Īug. March 2002: The FBI says it will refer the case to the Oakland County prosecutor’s office for possible state charges. June 2001: The head of the FBI’s organized-crime unit says in a court document that he believes a decision whether to prosecute anyone could be made in the next two years. The FBI finds no evidence to support the claim. Hoffa’s body was “ground up in little pieces, shipped to Florida and thrown into a swamp,” Allen said.ġ989: Self-described hit man Donald “Tony the Greek” Frankos claims Hoffa is buried under Giants Stadium in East Rutherford, N.J. Senate committee that Hoffa was killed at Provenzano’s orders. 1982: Self-described mafia murderer Charles Allen, who served prison time with Hoffa and participated in the federal witness-protection program, tells a U.S.Six suspects in the disappearance, including Provenzano and Anthony Giacalone, are convicted on unrelated charges. During the period, more than 70 volumes of files are compiled, containing more than 16,000 pages. More than 200 FBI agents are assigned to the case in New Jersey, Detroit and at least four other cities.2, 1975: A grand jury convenes in Detroit to investigate the Hoffa disappearance. They find fingerprints of family friend Charles “Chuckie” O’Brien on a 7-Up bottle under the right front seat. 8, 1975: The FBI gets a search warrant for Hoffa’s car, which was found in the restaurant parking lot. The 62-year-old Hoffa never is seen or heard from again.Īug. from a pay phone and tells her no one showed up for his meeting. Hoffa calls his wife, Josephine, about 2:15 p.m. at the Machus Red Fox restaurant in Oakland County’s Bloomfield Township to meet reputed Detroit mob enforcer Anthony “Tony Jack” Giacalone and alleged New Jersey mob figure Anthony “Tony Pro” Provenzano. and makes a stop to visit a friend in Pontiac. July 30, 1975: Hoffa leaves his Lake Orion home about 1 p.m. A chronology of events in the disappearance of Jimmy Hoffa, former president of the Teamsters union: Label-free tomographic phase microscopy is an excellent candidate to perform this task. High-throughput single-cell analysis is a challenging task. The proposed method is validated on both simulated and experimentally measured data. One of our key insights is that it is possible to obtain an explicit formula for computing the gradient of our nonlinear forward model with respect to the unknown object, thus enabling fast image reconstruction with the state-of-the-art fast iterative shrinkage/thresholding algorithm (FISTA). This expansion guarantees the convergence even for strongly scattering objects. Specifically, it corresponds to a series expansion of the scattered wave with an accelerated-gradient method. The proposed forward model can account for multiple scattering, which makes it advantageous in applications where linear models are inaccurate. In this paper, we describe a new technique-called Series Expansion with Accelerated Gradient Descent on Lippmann-Schwinger Equation (SEAGLE)-for robust imaging under multiple scattering based on a combination of a new nonlinear forward model and a total variation (TV) regularizer. Multiple scattering of an electromagnetic wave as it passes through an object is a fundamental problem that limits the performance of current imaging systems. An implementation of the proposed algorithm can be accessed and executed through a Code Ocean compute capsule. The processing of experimental data from synthetic aperture radar showed the capability for processing real images, including removing phase dislocations. When compared to the 2D windowed Fourier transform filter, SPUD performs better in terms of phase error and execution times. Simulation results with different levels of noise and wrapped phase fringe density reveal the suitability of the proposed method for accurate phase unwrapping and restoration. The proposed method relies on the least-squares Discrete Cosine Transform (DCT) solution for phase unwrapping with an additional sparsity constraint on the DCT coefficients of the unwrapped solution. In this paper, we present a non-iterative Simultaneous Phase Unwrapping and Denoising algorithm for phase imaging, referred to as SPUD. However, including a denoising stage increases the overall computational complexity resulting in long execution times. Recent methods for phase unwrapping in the presence of noise include denoising algorithms to filter out noise as a pre-processing stage. Second, T cells from the sample are separated and activated. First, the patient's white blood cells (those involved in disease-fighting) are collected. By engineering T cells to become smarter at recognizing (and attacking) a patient's cancer cells, Kite's biotechnology can potentially deliver the silver bullets for many seemingly hopeless cancer patients.Īs a personalized medicine, ETCs therapeutic is engineered in various steps. In contrast to other diseases, cancers are quite adept at evading attacks by the immune system via evolving their cellular targets. Similar to "the general" of an army, the thymus ("T") cells are key intelligence units of the body's defense system (coined the immune system), that direct the combating of diseases like cancer. That being said, we'll walk readers through the complexity of Kite's engineered T cells therapies ("CAR-TCR"). For most development-stage biopharma firms, the alluded intrinsic values resides in the efficacy and safety of its therapeutics (as indicated by the drugs' mechanism of action and trial data results). So that leaves us with the task of assessing Kite's true worth. "Oracle of Omaha" Warren Buffett stated that, while share price tends to fluctuate in the short term, it will almost always match the intrinsic value of a company in the long term. As the winds of fortunes - illustrative of the corporate developments and promising early trial results - have enabled the stock to soar by more than 200% in the past four years, the elephant in the room is whether Kite will continue its flight trajectory. To increase the chances of ETCs success, Kite partnered with Alpine Immunes Sciences in 2015 for the access to its Transmembrane Immunomodulatory Protein ("TIP") that, in and of itself, enhances the functioning of ETCs. This biotechnology can potentially deliver the biggest cancer treatment breakthrough since the introduction of chemotherapy more than half a century ago. With the dramatic results seen thus far in early clinical trials (and especially the cancer remission witnessed in refractory cases), the firm has reasons to pride itself as the leader in ETCs. Talk about room for ROI! Especially considering the Kite got $11.9B for only one mRNA patent and didnt even have one FDA clearance! We have two:Īnd they are both being Reactivated if Koos can beat the buyout:įirst Offical Reddit Post.Based in Santa Monica, California, Kite Pharma ( NASDAQ: KITE) is dedicated to the delivery of cancer therapeutics through the innovative engineered T cell therapy ("ETCs") platform. I trust those who want to can find those!Īnd, yes, its true, our IP was progressed with offical collaborations from Eli Lilly along the way:Ĭurrent Regen Market cap of about $80M. There are many more Patents listed still with USPTO. Now put the last two links together in your mind. This confirms the IP Regen owns with NR2F6. Then may I suggest you research the newest patent activity list in this $RGBP 8K: So this above Government Publication strongly confirms the significance of NR2F6. gov publication specifically on it 8 days ago: Not only every potentially reactive molecule/compounds(part of Eli Lilly Work), but Regen also patented the way to test and discover more activity with NR2F6. So What does Regen own? In a nutshell: Just about every aspect of Nuclear Cell Receptor NR2F6. Not only that but advanced IP! With INDs. With Todays undeniable focus on attaining mRNA advances by the big boys, I honestly cant find a better mRNA IP equiped company. Not trying to turn this into to anything but cliff notes. Santosh Kesari, Eli Lilly and Company, Oregon State University. The Working IP and Collaborative History of Regen is Undeniable: Dr. Thousands of Lab hours behind Regen, and Big Pharmas pay Big bucks for cutting edge advances which offer them cutting edges in lab time. As-Is! With the two INDs reactivated(or their ownership rights transfered as part of $20B) That number is repeatedly been offered to me in a strictly scientific research and Intellectual value. Regen Biopharma will either raise(or has raised) enough capital to solve its clerical issues(which it is obviously in progress of) and fund carrying the mRNA therapies it has locked up to market, or Regen is bought out by Big Pharma: Truly only one of two possible scenarios. $RGBP $RBGPP Details: ✅ $19m in Debt ✅ 2 FDA Cleared IND ✅ 20+ #mRNA Patents #NR2F6 ✅ Massive Global mRNA Focus Kite Pharma Details: ⭕️ $500m in Debt ⭕️ 0 FDA Cleared IND ⭕️ 1 #mRNA Patent ⭕️ No mRNA Attention Whilst that means the text is crisp and clear, it does mean that the bounding boxes for everything have to be calculated, and this is probably where the problem lies. When using a non-Aero theme, uTorrent has to do the scaling and only scales the text. It also has no ads, which is really nice considering how many there were. Additionally, it also includes smart features like hibernating your desktop after downloads have finished. 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A six-card collection of Magic: The Gathering cards from the original Power 9 set, considered some of the most powerful cards in the game, are available for a total of $845,000. Through prototyping, the capture tool created in QCTools treats the tape as a stream of data that it evaluates in real time. From cavorting with a group of testers and from participating in Hack Day at the 2014 Association of Moving Image Archivists conference in Savannah, Georgia, our team accrued further insight into how a capture-savvy QC Tools might work: In the spirit of knowledge-sharing and collaboration that exists amongst AV preservation community, the development team behind QCTools looked to preservationists and archivists for feedback in order to take their needs into consideration and to design a tool specifically for them. With support from the Knight Foundation’s Prototype Fund, the primary goal of this project is to position QCTools as a free, open source video capture tool designed for archivists and preservationists.Īs a tape capture tool, QCTools will feature a set of real-time analysis options previously unavailable to those who digitize magnetic media. This is precisely the rationale behind attempting to integrate capture functionality into BAVC’s QCTools. What if there existed a preservation standard software that was not only supported by modern computers, but one that would allow archivists the ability to perform quality control and check for video errors concurrently, as they captured? If there’s one thing we can’t afford to lose in the field of audiovisual preservation, it’s time. All you can do is take note of the timecode where you thought you noticed the error and go back to that moment later, with fingers crossed.Ĭhances are that if you’ve digitized media you’ve experienced both of these situations and have lost a fair amount of precious time re-doing work and/or navigating through the depths of technical support forums. There’s no way for you to check, however, while the video is being captured. In your peripheral vision, you notice something flit across the frame. You’re sitting at your computer, watching your content play in real time as you capture a videotape through a particular software. As a result, you fall back on old standbys only to discover that old software doesn’t play nicely with new hardware and you don’t know where to turn. You soon discover, however, that your out-of-the-box capture software doesn’t meet preservation standards. You’ve just purchased an expensive new computer with all the bells and whistles including professional capture software. We are glad to talk about the subject further with anyone interested.If you’ve digitized magnetic videotape before, perhaps you’ve experienced the following situation: The aim will be to increase confidence in our results without wasting time running after false positives that result from poorly chosen thresholds on any of the characteristics we track. So with the support of others in the AV Preservation community, we’ll be training our minds on how to interpret QCTools data, and subsequently creating some objective QC standards for our work. And the fact that they quantify what can otherwise be very qualitative judgements is also useful. So software packages like QCTools, able to automate the identification of a broad range of potential issues throughout a file, are very useful. We only routinely check beginning, middle, and end of files for obvious problems. But it is not practical for us to listen to and/or watch every piece of program material in its entirely. Batch processing promises to help us take advantage of this tool set in our regular workflow, instead of the very selective use we’ve made to date, when some video artifact in a file seems rather suspicious and/or unfamiliar to us.įor folks who are unfamiliar with our work, we use our trained eyes and ears everyday, as a form of quality assurance, in identifying potential issues with analog-to-digital transfers of the audio-visual media that we process. On day two, we got familiar with new batch file processing capabilities and discussed what other features we’d like to see. On day one, the group reviewed current QCTools features and operation. I was grateful Cornell granted me the time to participate. In late April, the group of approximately 15 people, all doing similar kinds of work, came together from all over the country, using grant money secured by BAVC. Olin Library’s Audio-Visual Preservation Lab (AVPL) was honored with an invitation to participate in a focus group aimed at identifying potential improvements to QCTools, a well respected suite of video quality control tools developed under the umbrella of the Bay Area Video Coalition (BAVC) in San Francisco’s Mission District. AV Preservation Lab participates in Video QC software focus group Firstly, the objective differences are weight and weather/terrain proofing. To answer a burning question for all of those current Loka owners, “Do I upgrade to the Loka Ultralight?” the answer isn’t simple. The ICUs themselves can be jammed in via the back door or via the secret (OK, not so secret but it was a few days before I’d discovered it) opening at the top, which allows for the ICUs to be slipped in without needing any muscle. The hydration bladder fits inside a sleeve on the interior, backside of the ICUs. You access your camera gear via the flappy door also acting as your back padding. It has space for a hydration bladder and the forward facing port for the tube to come out. The hard plastic waist buckle on every bag I’ve ever owned will somehow always find a way to stab me and no one needs that. Furthermore, with a plethora of attachment points, additional pieces of gear such as skis, hiking poles or even a snowboard can easily be loaded.Īlso, kudos to f-stop Gear for doing something I love and putting the hip belt buckle on the left padded waist arm instead of placing it smack dab in the middle of the belt. It has all the pockets in all the right spots and includes an internal aluminum frame to better distribute the load on your back. In effect, the Loka UL is just like any other backpack you might find. Keeping the comparisons going while glancing at the weight of several other bags in the same class as the Loka Ultralight, and they all weigh in at between two and six pounds heavier. My first experience hiking with it, packed with a Nikon’s D800, 300mm f/2.8, 24-70 and 14-24 and I actually said to a friend “I’ve forgotten I have a backpack on.” He carried it for the next 200 yards or so and had the same sentiments. Floating like a butterfly on your back while you sting photos like a bee. With that out of the way, lets finally get to the bag. No need to change backpacks, just swap the ICU. Having a full-sized Large ICU and a Small ICU lets you go whole hog or half hog, depending on your needs. When you factor those two features against the less than free wheeling competition, the choice may become easier for you. The next it’s a full day hike with plans to eat breakfast, lunch and supper beside the campfire. One day it’s a three-hour hike with the goal of shooting a specific set of photos and getting the hell out of there. It’s positively my most favorite aspect of all the f-stop Gear Mountain Series camera backpacks.Īs I’ve said before, I’m all over the place. There’s no end to the level of adjustments and packing options with the ICUs. The most appealing part of the ICU system is its customization factor, it is off the charts. Eventually you’re on a job that requires your Magic Arm and it’s in your roller… at home. It’s tiresome, risky and something’s always missed. The task of repacking from one bag to another is one a lot of photographers deal with daily. If you’re the kind of person who does various activities each requiring their own bag type then the flexibility afforded by the ICUs is priceless. When you get right down to it, the f-stop Gear ICU methodology is comparatively inexpensive. Left to right: Shallow ICU medium w/ 70-200, Shallow small w/ D700+24-70, XL Pro ICU w/ D3+300mm 2.8 and 70-200 across the top. If this sounds like a lot, then you’ve obviously not shopped for a professional grade backpack this decade. With a price point of around $250 for the bag alone, stare another $60 to $100 in the face for an Internal Camera Unit (or two) and that $250 quickly becomes almost $400. If you’re fluent with f-stop Gear’s lineup, feel free to skip a few paragraphs, you already know why that grumbling is unnecessary. Nothing changes in this department, but for the uninitiated this may cause you to grumble a little. A streamlined revision of the original Loka, the new Loka UL will be the eighth bag in the Mountain Series.įirst and foremost for current subscribers to the f-stop way of life, it’s still an ICU backpack. And I’ll let you in on something else: they solved it a long time ago.īack country mountain men and women have been digging the f-stop camera back system for some time, and the endless vocal support found on many message boards speaks volumes about the quality you get for your money. |
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